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| Introduction |
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| The important characteristic of the gene is to store and express the genetic information that will contribute towards the phenotype, and will be passed on to successive generation. |
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| The idea that genes control the metabolism was put forward as early as 1902 by Gannod. He studied several human disorders, which seems to be inherited. He called them inborn errors of metabolism. |
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| Subsequently a number of human diseases were identified and described which fell into the category of inherited metabolic defects. It, thus, led to the idea that many disorders may be inherited as any other gene and that genes function by controlling the metabolism. |
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